DZIF Antibody Core (Ab-Core) Platform

DZIF-Ab-Core is a central platform for the rapid and comprehensive evaluation of new antibody candidates for the prevention and treatment of infectious diseases. DZIF-Ab-Core provides state-of-the-art technological support for researchers within the DZIF network to effectively address global challenges such as antimicrobial resistance and emerging viruses. Through a secure online interface, members can submit antibody sequences and select from a range of specialized tools and analyses - flexibly and on a need-based basis. Preclinical analyses and antibody production are carried out across sites by experienced partners within DZIF. Services offered by the DZIF-Ab-Core platform: Online interface for structured submission and project planning; Evaluation of antibody sequences (e.g., liability assessment); In vivo analyses for PK determination in relevant models; Structural analyses as well as poly- and autoimmunity reactivity testing; Assessment of manufacturability and mid-scale production; Fc engineering and functional characterization of Fc-mediated effectors.

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