This is a prospective, multicenter, observational study (mEX-TB study) of patients with extrapulmonary tuberculosis (EPTB). Adult patients newly diagnosed with EPTB will be prospectively enrolled. Clinical data will be collected using standardized questionnaires throughout the treatment period for each individual. In addition, body fluids (blood, urine) will be collected and stored in a central biobank. Biomarkers in EPTB patients will be analyzed during treatment and correlated with clinical data. Furthermore, a healthy control group will be added, which will primarily serve as a technical control for complex laboratory procedures such as RNA-seq and T-cell based assays. The mEX-TB study study is a multicentre continuation of a pilot study (EX-TB study) that has been running at German Center for Infection Research (DZIF) since 2018. This study is funded by the DZIF.